There was demyelination of the optic nerves, but a gross examination of the brain was unrevealing. Autopsy disclosed severe demyelinating and necrotic lesions extending 4–5 cm length in the lower thoracic and lumbar spinal cord. One month later, she developed urinary retention, complete paraplegia and blindness, and died few weeks later. Devic reported the case of a 45-year-old French woman who was seen at the Hôtel-Dieu hospital of Lyon because of an intractable headache and depression in addition to general asthenia. The term neuromyelitis optica was introduced by Eugène Devic and Fernand Gault in 1894, who first recognized the association of amaurosis and myelitis as a new clinical entity. In line with that, N-methyl-D-aspartate receptor-IgG and CV2/CRMP5-IgG have been described in association with NMOSD phenotype. On the other hand, failure to identify either AQP4-IgG or MOG-IgG in a proportion of patients with NMOSD phenotype supports the view that other autoantibodies or factors may also play a role in NMOSD pathogenesis. The lack of coexistence of AQP4-IgG and MOG-IgG in the serum of a same patient further suggests that AQP4-IgG NMOSD and anti-MOG syndromes are distinct diseases. Moreover, three fourths of NMOSD patients test positive for AQP4 antibody, while serum MOG antibody is only detected in a minority of seronegative AQP4-IgG NMOSD patients. Because of this particular location, MOG is a good antigen candidate for autoimmune demyelination. Whereas NMOSD is most frequently associated with antibodies which target aquaporin-4 (AQP4), the most abundant water channel in the CNS, particularly expressed in the astrocytic processes at the blood-brain barrier (BBB), anti-MOG syndromes result from damage to myelin oligodendrocyte glycoprotein (MOG), a membrane protein expressed on oligodendrocyte cell surfaces and on the outermost surface of myelin sheaths. Īlthough NMOSD and anti-MOG syndromes share a number of clinical manifestations, they are independent nosological entities with distinct pathophysiological mechanisms and histopathological features. Even a more important reason is the observation that some agents used in MS treatment may be deleterious to patients with NMOSD. Early and accurate diagnosis of these distinct conditions is very relevant as they have different therapeutic approaches. Because of their clinical manifestations and habitual relapsing course, they are frequently confounded with multiple sclerosis (MS). Neuromyelitis optica spectrum disorders (NMOSD) and anti-myelin oligodendrocyte glycoprotein (anti-MOG) syndromes are immune-mediated inflammatory conditions of the central nervous system (CNS) that frequently involve the optic nerves and the spinal cord. Promising emerging therapies for NMOSD include monoclonal antibodies and tolerization. Attacks are usually treated with steroids, and relapses prevention with immunosuppressive drugs. Acute disseminated encephalomyelitis and bilateral or recurrent optic neuritis are the most frequent anti-MOG syndromes in children and adults, respectively. Other core clinical characteristics include area postrema syndrome, brainstem, diencephalic and cerebral symptoms that may be associated with typical MRI abnormalities. Acute transverse myelitis with longitudinally extensive lesion on spinal MRI is the most frequent inaugural manifestation of NMOSD, usually followed by optic neuritis. On the other hand, anti-MOG syndromes result from damage to myelin oligodendrocyte glycoprotein (MOG), expressed on surfaces of oligodendrocytes and myelin sheaths. NMOSD is frequently associated with antibodies which target aquaporin-4 (AQP4), the most abundant water channel in the CNS, located in the astrocytic processes at the blood-brain barrier (BBB). Some agents used for MS treatment may be deleterious to NMOSD. Early and accurate diagnosis of these distinct conditions is relevant as they have different treatments. Because of their similar clinical manifestations and habitual relapsing course they are frequently confounded with multiple sclerosis (MS). Neuromyelitis optica spectrum disorder (NMOSD) and anti-myelin oligodendrocyte glycoprotein (anti-MOG) syndromes are immune-mediated inflammatory conditions of the central nervous system that frequently involve the optic nerves and the spinal cord.
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As Oz had no leadership at the time, he became Supreme Ruler of the kingdom and did his best to sustain the myth. One day his balloon sailed into the Land of Oz and he found himself worshipped as a great sorcerer. Working as a magician for a circus, he wrote OZ (the initials of his first two forenames, Oscar being his first, and Zoroaster being the first of his seven middle names) on the side of his hot air balloon for promotional purposes. When, at last, he grants an audience to all of them at once, he seems to be a disembodied voice.Įventually, it is revealed that Oz is actually none of these things, but rather an ordinary conman from Omaha, Nebraska, who has been using elaborate magic tricks and props to make himself seem "great and powerful". In each of these occasions, the Wizard appears in a different form, once as a giant head, once as a beautiful fairy, once as a horrible monster, and once as a ball of fire. Oz is very reluctant to meet them, but eventually each is granted an audience, one by one. Believing he is the only man capable of solving their problems, Dorothy and her friends travel to the Emerald City, the capital of Oz, to meet him. Unseen for most of the novel, he is the ruler of the Land of Oz and highly venerated by his subjects. The Wizard is one of the characters in The Wonderful Wizard of Oz. The character was further popularized by a stage play and several films, including the classic 1939 film and the 2013 prequel adaptation. Oscar Zoroaster Phadrig Isaac Norman Henkle Emmannuel Ambroise Diggs (also known as the " Wizard of Oz" and, during his reign, as " Oz the Great and Terrible" or the " Great and Powerful Oz") is a fictional character in the Land of Oz created by American author L. 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In these free creative writing classes, you’ll find many writing resources, including tips to quickly and easily organize your book, writing exercises to improve your writing speed, and more. This will help you stay focused on what you need to include in your book and eliminate any superfluous information. Focus on getting the general outline of your story or your non-fiction book structure down first. While professional writers may have extensive training in grammar, syntax, and other technical aspects of writing, writing at its core is simply communicating a story from one person to another.Īs such, try not to get too bogged down in the details when first starting out. Once you have your basic story idea, don’t get bogged down in the details of character development or plot points just yet. Once you have your topic, you will need to do some research and curate content and information on your chosen subject. If you don’t think you have a story worth telling, spend some time brainstorming until you come up with an idea that feels right for you. This can be something you are passionate about or have extensive knowledge of.Įveryone has at least one story to tell or some unique ideas to share. So, you will need to come up with an idea for your book. Come up with an idea for your bookįirst and foremost, remember that writing is ultimately about storytelling. Here are a few things you will need to do in order to write a book without being a professional writer. It takes a lot of effort, time, and commitment to write a book that is of good quality. While it is possible to write a book without being a writer, it is important to note that writing a book is not an easy task. So if you’re wondering how to write a book without being a writer, here are a few tips and tricks to help get you started. You don’t need to be a professional writer to write a book. You can still be a writer! In fact, some of the most popular and well-known writers who have successfully written books originally had little to no experience with writing whatsoever.īecoming a successful writer is more a matter of having interesting ideas and stories, or sharing the knowledge and experience you have gained over a lifetime, and that people in your field would love to learn about. No writing degree or certification? No problem. Want to write a book but don’t have the writing skills or confidence? These book writing tips will show you how to write a book without being a writer. Related: CubeSats: Tiny, Versatile Spacecraft Explained (Infographic) Those payloads include the Orion space capsule's crew survival systems (NASA has a new launch and entry spacesuit for astronauts onboard), as well as the ArgoMoon and NEOScout cubesats.ĪrgoMoon is designed to take autonomous imagery of the SLS rocket's upper stage, called the Interim Cryogenic Propulsion Stage, and was built by the Italian company Argotec with support from Agenzia Spaziale Italiana, the Italian space agency. 16.) In that briefing, agency officials will discuss the technology demonstration and solar system science payloads riding aboard the mission. 16: Artemis 1 technology & solar system science Joseph Shoer, architect for Small Sat missions, Lockheed MartinĪug.Ben Malphrus, NASA principal investigator, Lunar IceCube.Ryu Funase, project manager for EQUULEUS, JAXA.Tatsuaki Hashimoto, project manager for OMOTENASHI, Japan Aerospace Exploration Agency (JAXA).Craig Hardgrove, principal investigator, LunaH-Map, Arizona State University.Jacob Bleacher, NASA chief exploration scientist."Each of the payloads will perform science and technology experiments in deep space, expanding understanding of lunar science, technology developments, and deep space radiation." "Ten shoebox-size secondary payloads, called CubeSats, are hitching a ride to space on Artemis I's Space Launch System (SLS) rocket, and several other investigations are flying inside the Orion spacecraft during the flight test," NASA officials wrote in an announcement. EDT (2100 GMT) to highlight the lunar science payloads riding on Artemis 1. 15), NASA held its first teleconference of the week at 5 p.m. will share that briefing schedule as soon as it is available. This week's webcasts will set the stage for NASA's Artemis 1 launch, which will likely have its own series of preflight briefings and webcasts. Splashdown is targeted off the coast of Florida so that the capsule can be retrieved and returned to the Kennedy Space Center, where it launched in July. 18 to bring about 4,000 pounds (1,815 kg) of supplies and science experiments to Earth. SpaceX's Dragon is expected to return to Earth later in the day on Aug. EDT (1505 GMT), while NASA's webcast of the departure will begin at 10:45 a.m. The SpaceX-25 Dragon cargo ship will undock from the station at 11:05 a.m. A SpaceX Dragon cargo ship will also depart the ISS to begin its trip back to Earth on Thursday, Aug. 18: SpaceX-25 Dragon cargo ship landingĮxtra webcast! The Artemis 1 rollout is not the only space event this week. EDT (1300 GMT) and will track Russian cosmonauts Oleg Artemyev and Denis Matveev as they work outside the station's Russian segment. Desai, CuSP principal investigator, Southwest Research Institute (SwRI)Įxtra webcast! In addition to the Artemis 1 briefing, NASA will also webcast live views from a Russian spacewalk at the ISS on Wednesday. Sergio Santa Maria, BioSentinel lead scientist, NASA's Ames Research Center.Ye Zhang, plant biology program scientist, NASA Biological and Physical Sciences.Oren Milstein, chief executive officer, StemRad.Thomas Berger, Helga and Zohar principal investigator, German Aerospace Center.Ramona Gaza, MARE science team lead, NASA's Johnson Space Center.Here's who will discuss the space radiation goals of Artemis 1: The mission will also include plant experiments and BioSentinel, a cubesat that will grow yeast in the deep-space radiation environment over the course of a year. Related: How NASA's Artemis moon landing with astronauts worksĪmong them is the StemRad radiation vest, which will be worn by one of two dummy torsos on the Orion spacecraft to measure the radiation environment. To understand the risks of space radiation, as well as to develop countermeasures, Artemis 1 is carrying several payloads for scientists. The astronauts on those long moon missions will be subject to a much harsher radiation environment than those in low Earth orbit on the International Space Station (ISS). Artemis 1 is the first mission of NASA's larger Artemis program, which aims to return astronauts to the moon, build a sustainable moon base and then aim for Mars. The diagnostic criteria for the two most common clinical disorders are extensive, but here is a review: The first step, of course, is for the individual to understand that there is a genuine problem, and he or she has the desire to remedy it. Depending on the seriousness of the disorder, correcting it may be accomplished by the individual through natural means or with the help of professionals in the fields of both mental health and nutrition, although other health professionals may also be capable of successfully treating a patient with this condition. Regardless of the details, the condition creates ill health that can lead to injuries, especially stress fractures, hormone imbalance or mental problems such as depression.Ī disorder means there’s some physical, chemical or mental-emotional problem, typically a combination, which needs to be addressed. In some cases, one may be a pathogenic eater only during a competitive season, or only be obsessed with avoiding fat calories, while another may have ongoing unhealthy activities throughout the year. This problem is more prevalent in certain sports, especially if there is a need to meet a minimum weight, although endurance athletes believe just weighing less will improve performance, which is a fallacy when health is sacrificed in the process. This includes dieting, calorie restriction, reducing fat intake, fasting (not for health reasons), and the use of laxatives, diuretics and diet pills (and vomiting). As a result of the strict DSM-IV diagnostic criteria, the number of people exhibiting dangerous pathogenic eating behaviours is actually much higher than the prevalence of diagnosed disorders.”Įating disorders are sometimes referred to as pathogenic eating. In the British Journal of Sports Medicine, DePalma (2002) writes, “It is only after following these behaviours and meeting the strict DSM-IV criteria that a person is classified as having an eating disorder. For many people, their problems are never recognized or are only observed when a full blown clinical diagnosis becomes obvious. Of course, our society even encourages disordered eating. Too many people with disordered eating “fall through the cracks” of the healthcare system. Where a person exists on this spectrum, if at all, is often, but not always easy to discern. The problem can be classified in a much simpler way-disordered eating.Īustralia’s National Eating Disorders Collaboration states that, “Disordered eating in athletes is characterised by a wide spectrum of maladaptive eating and weight control behaviours and attitudes.” The same could be said for those not in sports, where disordered eating is also common. While this category greatly expands the condition of disordered eating to include many more people, rightly so, it may still not be enough. These cases, which may make up the majority, are referred to as subclinical eating disorders. They include anorexia nervosa, bulimia nervosa and eating-related problems “not otherwise specified.” The American Psychiatric Association says that the “not otherwise specified” category is for eating problems that do not meet all the criteria for any specific named eating disorder. As described in the Diagnostic and Statistical Manual of Mental Disorders (DSM), eating disorders are characterized by gross disturbances in eating behavior. These patients almost always require some type of healthcare to help remedy their problems. Mention eating disorders and most people think of the serious mental health conditions of anorexia nervosa and bulimia. Disordered eating appears to be a well-hidden epidemic in adolescents and adults, in both male and female, and is more common in athletes. The power liftgates can be controlled with a remote. The SE and STL liftgates are manual only. To release the lock just manually press the door higher. When pressed, the liftgate has a button that will lock the liftgate at the opening level you choose. The power liftgate is standard on the ST-LIne, Titanium, and Edge ST models. Does the Liftgate Lock in place on the Ford Edge? This is doable for short drives as long as the liftgate is locked or manually strapped in place. The difficulty is that it will also extend two-feet out of the back of the vehicle. With the second-row folded down, a sheet of plywood will fit at an angle over one of the wheel housings. Can a sheet of plywood fit in a Ford Edge?Ī standard sheet of plywood is four feet wide by eight feet long. Another option is to lower the second-row seats or just one side of them so the clubs can lay full length. The driver club, which has the longest length, might need to be removed not to hold any tension against the vehicle's frame. Golf clubs will usually fit at an angle in the cargo space, so there is no need to lower the second-row seats. Can you carry golf clubs in the Ford Edge? Another consideration is any packaging that the store might use that can be removed before transport. When checking the dimensions of height, width, and length, also note if the height is with or without the legs? Some legs on furniture easily unscrew. With the second-row seats down, you can carry some loveseats home. Can a loveseat fit in a Ford Edge?įolding the second-row seats down creates lots of cargo space. When you lift the cargo bed floor, you will find three pods of storage space adjoining the spare tire and jack. The Ford Engineers have taken space that is often wasted in other vehicles and added storage pods. With those seats up for passengers, the cargo bed has 34.5 cubic feet of carrying space. With the second-row seats folded flat, the total cargo space is 7.34 cubic feet. How Is Cargo Space Calculated?Ĭargo space's cubic volume is figured by multiplying the length by width by height to get the cubic foot measurements. This gives a lot of space for passengers and your stuff. The Ford Edge's exterior is 75.9 inches wide without mirrors with an interior beltline width of 63.3 inches and a wheel housings width of 45.3 inches. Ford Edge Cargo Options How wide is a Ford Edge? All models are manually folded back up for passenger seating.īy folding the second-row seats down, you can carry some longer items, with 74.8 inches from the liftgate to the back of the front row. The Titanium and ST models' seats have power fold. For the SE, STL, and ST-Line models, the latch to fold them is on the sides of the seat. The second-row bench seat folds flat on top of itself. In the middle is a fold-down with two cup holders that can be folded up, forming the back of the seat for a third person. The second-row is a 60/40 split-fold flat reclining bench that is most comfortable for holding two people in its outer seats with its 57.5 inches hip room and 60.5 inches shoulder room. The second-row passengers will still have four inches of space for their knees. The front bucket seats can be adjusted to easily fit a six-foot tall person. Ford Edge Passenger Seating OptionsĪll five models seat up to five passengers. The five models are the SE, STL, ST-Line, Titanium, and Edge ST. Like the bigger 2021 Ford Explorer, the new Ford Edge has options for configuring the seating and cargo space. The Ford Edge sits between the smaller Ford Escape and the Ford Explorer. The square design makes carrying boxes easy. You have room for some furniture, even a small loveseat. With the 60/40 split-folding bench seat, you have more cargo-carrying space. Now that we have the numbers, what do they mean for carrying capacity and storage? The Ford Edge has lots of storage options. Cargo bed width between wheel housings – 45.3 inches.Cargo bed width at beltline – 63.3 inches.Length behind 2nd-row seats – 41.7 inches.Volume behind the 2nd-row seats – 39.2 cubic feet.Length behind 1st-row seats – 74.8 inches.Volume behind 1st-row seats – 73.4 cubic feet.The second-row seats fold flat in all models. The research on the Ford Edge's cargo dimensions is here so you can make the best buying decision.įord engineers have made the cargo space the same for all five models and trim levels. Or you can fold down the second row for even more carrying capacity. With seating for five people, the Ford Edge still has lots of space in its cargo bed. When considering a new SUV, the Ford Edge is worth a look for its two-row seating and surprisingly spacious cargo space. You have to run cfw before playing any injects. What is your setup are you using external hard drive, internal or flash drive and what cfw are you running. It could be not running cfw, your external hard drive (especially if you're using a flash drive not recommended) or something like that but it's not the key. item 4 Rhythm Heaven Fever (Nintendo Wii, 2012) W/Case Manual & Insert Tested & Working Rhythm Heaven Fever (Nintendo Wii, 2012) W/Case Manual & Insert Tested & Working 129.99 +5. Your game crashing is not because of the key if it was the key the injection would have failed on your computer in the first place. Posts automatically merged - Please don't double post!. 01, if Im not mistaken, is Nintendos company code. You might even say that its a lot like a not-terrifying clown at a kids. the first four are the product code, the last two are the last two numbers of the company code. Rhythm Heaven Fever (Wii) Rhythm Heaven games are the kind whose sole purpose is to make you smile. Then you don't have to worry about keys anymore. you can get these codes from the meta.xml for wiiu vc games. So just enter the Wii U title key one time as well as rhythm heaven key into the injector. Com Top key searches: Rhythm Heaven Fever Super Smash Bros Wii U Zelda Breath. Developers Nintendo SPD Moby Score 7. If you can't get it to work delete hosts.json from your launcher folder. The only reason to use the compatibility list is to make sure a game works (99% do) but also in case you want to use the gamepad instead of play with Wiimote it tells you which games work and you can change settings in the injector to make the gamepad work but only for those games that work with it. Wii U USB Helper needs the title key web site to WiiU Title Key has almost. Released July 21st, 2011 on Wii Credits 71 people Releases by Date ( by platform) 2011 ( Wii ) 2016 ( Wii U ) Publishers Nintendo Co., Ltd. I noticed that the site you mentioned is missing the tickets of the Just Dance 2019 updates for the EU and US regions (title IDs: 0005000E102170000E10217300), perhaps you want to add those as well. It stores it in temp folder.ĭon't worry about where the compatibility list says "use x key for x game" it's not important as that was meant for an older app that was made before TeconMoon's Wii VC Injector. Yes you enter the key one time as well as the Wii U title key, and as long as your PC doesn't completely crash where you lose all your data you can inject any game as long as the compatibility says it works. Despite these affirmations, there is no information regarding a new title in the series being developed. On July 31th, 2020, he tweeted in celebration of the fifth anniversary of Rhythm Heaven Megamix, reaffirming a desire for a Switch title, and on June 16th, 2022, he retweeted a fan request for a new title on Switch. Later on April 9th, 2020, he replied to a post regarding his interest in continuing the series, expressing ideas for what features a title on Nintendo Switch could have. Hi I recently homebrewed my Wii u and am now trying to get wii u usb helper. Top key searches: Rhythm Heaven Fever Super Smash Bros. comments sorted by Best Top New Controversial Q&A Add a Comment marleyhead Additional comment actions. Best Wii U USBHelper Title Key Site So I downloaded USBHelper to use with the latest version of. On May 8th, 2019, he retweeted an article about the game, asking fans what they think is revolutionary about the series. Rhythm Heaven Fever, Super Smash Bros Wii U, Zelda Breath Of The Wild Key Cemu. Anyone know anything about a wii title key site Wii U USB helper update. Fates puts players in the middle of a conflict between two families: the Hoshido and Nohr. In the years since the release of the previous title, series producer Tsunku♂ has expressed interest in developing a new game. Revelations is the third campaign from 2016's Fire Emblem Fates. Make sure to choose the same email used for the Luminar AI purchase. If you don’t have an account, you can create it here. If you already have an account, sign in with Google, Facebook, Microsoft, Apple, or your email and password. 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